Argonne National Laboratory


The Advanced Protein Characterization Facility (APCF) establishes state-of-the-art laboratories, integrated with a scientific collaboration facility, for the production, characterization and crystallization of proteins. Linked to the Advanced Photon Source (APS), the APCF efficiently delivers crystals to the powerful X-ray beamlines of the APS and takes full advantage of Argonne’s facilities for determining three-dimensional structures of proteins and other biological macromolecules. The APCF also characterizes protein functions and studies their interactions with other macromolecules and small ligands.

Funded by the State of Illinois, the $34.5-million facility attracts scientists from universities, research institutes and biotech companies from across the nation by offering researchers the most advanced technologies for studying new classes of proteins and protein complexes.

The APCF enhances Argonne’s structural biology efforts by providing a carefully designed, highly specialized and adaptable laboratory space devoted to working with the most challenging classes of proteins and macromolecular assemblies, work that was previously limited by existing infrastructure. Furthermore, the APCF has the automated laboratories and modern computational capabilities needed to support emerging Argonne activities in systems and synthetic biology. This state-of-the-art facility provides researchers with the most advanced technology and expertise for protein science experiments in Illinois and the nation.