Argonne National Laboratory


Argonne National Laboratory, The University of Chicago, and other institutions engaged in systems, synthetic, and structural biology are performing their research at the Advanced Protein Characterization Facility (APCF). Three of the largest research projects are as follows:

  • The Midwest Center for Structural Genomics (MCSG), a component of the Protein Structure Initiative (PSI), is supported by a grant from the National Institutes of Health (NIH). The MCSG has developed a platform that produces more protein structures than almost any other organization in the world. Earlier MCSG laboratories were dated and did not provide the space or environmental controls necessary to support the advancement of research programs, development facilities, and planned growth. The APCF establishes a state-of-the-art, highly automated laboratory and scientific collaboration facility to produce and characterize proteins and growing protein crystals. Single protein crystals are needed to take full advantage of Argonne’s capacity for determining the three-dimensional structures of proteins and other macromolecules.
  • The Center of Structural Genomics of Infectious Diseases (CSGID), funded by NIH, focuses on determining the structures of potential protein drug targets and their complexes with inhibitors from human pathogens.
  • The Structural Biology Center (SBC), funded by the U.S. Department of Energy Office of Biological and Environmental Research (BER), provides advanced, semi-automated data collection and structure determination facilities for the structural biology community at Argonne's Advanced Photon Source. SBC research focuses on proteins relevant to the BER mission, especially plant and bacterial proteins, and on improving hardware and software for data collection at synchrotron beamlines.