Nanoparticles can be redox mediators within cell machinery

By Jared SagoffApril 1, 2010

Titania semiconductor-based hybrid nanomaterials are capable of integration with biological molecules and bio-systems. We (E. A. Rozhkova et. al) have shown that these hybrids have exquisite control over energy and electron transfer that mimics natural energy-transducing processes. Modification of the titania surface with functional ligands may affect the formation and “spatially resolved” production of reactive oxidative species (ROS). This allows one to control and direct site-selective redox chemistry that can be employed to alter (or trigger) cell functioning.

These results were highlighted by the American Chemical Society Office of Public Affairs and were reported in several international and domestic invited talks. The microprobe studies were conducted at the Advanced Photon Source (APS).

Citation Information: J. Amer. Chem. Soc. 131, 2893-2899 (2009); Nano Letters 9, 3337-3342 (2009); and Handbook of Nanophysics, Functional Nanomaterials, ed., K. D. Satter, CRC Press (2010), in press.

Authors: E. A. Rozhkova, N. M. Dimitrijevic, T. Rajh, J. Maser, V. Rose, B. Lai,3 I. Ulasov, and M. Lesniak.