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The Computing, Environment, and Life Sciences (CELS) directorate integrates Argonne’s research in the life sciences (subsurface science, terrestrial ecology, molecular biology, microbiology, protein chemistry, bioinformatics, and computational biology) with the environmental sciences (earth science, energy science, and global climate research), and the computing sciences (applied mathematics, data science, and computational science) and has established a leadership computing facility essential for advanced simulation.