Argonne’s efforts in biodetection technology focus on environmental molecular microbiology and technology development, with an emphasis on low-cost, microarray-based, diagnostic, integrated systems that can be deployed at the point of use. Principal biological applications include national security, the detection of threat agents and pathogens in environmental and clinical samples and the analysis of environmentally-relevant microorganisms for bioremediation.
Many facets of Argonne’s work involve biochip technologies -- high-density arrays of individual test sites immobilized on a glass, plastic or micro-particle substrates. Thousands of individual test sites are spatially arrayed into a 1-by-3-inch (25 x 75 mm) area or collection of micro-particles, such that a single droplet of sample can be analyzed for hundreds to thousands of biological molecules (DNA, RNA, proteins, metabolites) simultaneously.
Argonne's biodetection technology work includes:
- Application of Oligonucleotide Protein Arrays for Advanced Mutant Analysis and Proteomic Studies
- Integrated Nucleic Acid System for In-field Monitoring of Microbial Community Dynamics and Metabolic Activity
- Universal Fingerprinting Chip for Microbial Forensics and Source Attributions
- Multiplexed Pathogen Detection by On-chip Amplification
- Development of Point of Care Genetic Diagnostic
- Biological Microchips for Pathogenic Bacterial Identification