Argonne National Laboratory

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Inorganic Control of Biological Self Assembly

NST Nanoscience Colloquium
Akif Tezcan, University of California, San Diego
September 10, 2014 4:00PM to 5:00PM
Building 440, Room A105-106
1, 2 and 3-dimensional protein arrays play central roles in diverse biological processes, are widely used in nano/biotechnological applications, and form the basis of protein crystallography. The design of an arbitrary protein that can self-assemble into such arrays is very desirable, but complicated by the chemical heterogeneity of protein surfaces. We have shown that through enginereed metal coordination, monomeric proteins can be assembled into helical 1D nanotubes, and 2- and 3D arrays with crystalline order. These assemblies show striking similarities to highly evolved architectures like microtubules and bacterial S-layers in terms of their shapes, dimensions and structural uniformity, as well as their responsiveness to chemical triggers. The assemblies can be uniformly functionalized on the level of an individual building block, providing a route for creating homogeneous nanoscale materials.