Magnetic Nanohybrids for Thermo Chemo Therapy
Magnetic nano particulates (MNPs) with different shapes, composites, hybrids, core shell structure and magnetic fluids have been developed by various soft chemical methods. Magnetic nanostructures with sufficient biocompatibility are the best candidates for several therapeutic and diagnostic applications such as treatment for cancer through hyperthermia, targeted and sustained drug delivery, as contrast agents and other bio sensing applications. We discuss here some of these aspects based on the work carried out in our laboratory. In addition, we discuss development of multifunctional magnetic hybrid nanostructures, which may be used for a combined therapeutic and diagnostic approach.
For efficient delivery of magnetic nano particulates with drug to the diseased site, magnetic fluid based release systems will be discussed with different possibilities of thermo sensitive and pH sensitive hydrogels, liposomes and dendrimers as carrier. These encapsulate of chemotherapeutic drug and MNPs with tagging targeting moiety (like folic acid) on the surface have been investigated. We will particularly emphasize some of our recent in vitro as well as in vivo results on lipid and hydrogel based nanohybrids with multifunctional capabilities. We have further investigated the synergistic effects of dual drug and dual therapy.
The deliberate design of nanoparticulates for biological applications has been enabled by new advances in synthetic procedures through different soft chemistry routes. Such nanostructures when properly functionalized can be used as effective vehicles for biological entities in vivo. In this respect we will also discuss some of the other porous nanostructures which we have used for specific drug delivery applications. In addition the mechanism of cell death during controlled experimental conditions for hyperthermia treatment of cancer will be discussed.