Mapping Mouse Brain Circuits
The talk will report on progress in the Mouse Brain Architecture Project http://mouse.brainarchitecture.org. We are employing a grid-based approach to map neuronal projections in the mouse brain. Each grid point is injected in individual mice with one of four neuronal tracers (two retrograde, two anterograde).
The brains are subsequently processed through a high throughput histology pipeline and imaged using slide scanning microscopy. The resulting data is being released on the web, providing a virtual microscope into these brains, and are also being subjected to computational neuroanatomical methods to extract information about long range projections in the mouse brain. The goal of the project is to provide a comprehensive picture of neuronal projection patterns across the whole mouse brain. The talk will detail ongoing work as well as preliminary findings.