Mechanisms of Magnetic Hyperthermia
Magnetic hyperthermia is the process by which cycling magnetic nanoparticles in a magnetic field leads to heat dissipation . It is a very attractive approach for the treatment of cancer and reduction in size of non-malignant tumors because it generates no side effects unlike more conventional therapies such as chemotherapy. However, at the present time the mechanisms by which heat is generated are not fully understood. Understanding these mechanisms is critical so as to produce particles with optimised properties for specific applications at nominal dose.
In this talk I will discuss the different mechanisms leading to heat dissipation in magnetic nanoparticles: susceptibility loss, hysteresis loss and viscous heating. A combination of experimental and theoretical results will be presented. It will be shown that heating experiments should be carried out in samples disperse in wax, i.e. solid matrix, to remove effects that will not occur in-vivo. The role of the distribution of anisotropy constants will be discussed.
 Q. A. Pankhurst, J. Connolly, S. K. Jones, J. Dobson, J. Phys. D: Appl. Phys. 36, R167 (2003)