Nanostructured Semiconductor Devices: From Chemical Synthesis to Biomedical Applications
Nanowire field-effect transistors (NWFETs) represent diverse and powerful nanostructures for achieving nanoscale bioelectronic interfaces with cells and tissue. NWFETs exhibit exquisite sensitivity in chemical and biological detection and can form strongly coupled electrical interfaces with cellular components. My talk will focus on several biomimetic design considerations towards breaking down the boundary between nonliving and living systems across multiple length scales.
I will describe how we experimentally apply these designs in the nanoelectronic systems for building electrically active, minimally invasive interfaces with single cells and synthetic tissue. Specifically, I will discuss a new synthetic approach and novel fabrication method to realize the first semiconductor transistor bioprobe for intracellular measurements from a truly three-dimensional nanoscale device. In addition, recent progress on nanoelectronically addressable synthetic tissue will also be discussed. Finally, I will describe the prospects in future fundamental studies and applications in the life sciences.