Template Direct Assembly of Bio-based Materials for Advanced Applications
Engineering at the nanoscale has been an active area of science and technology over the last decades. Inspired by nature, synthesis of functional inorganic materials using synthetic organic templates constitutes will be the theme of the first part of this talk. Developing organic template directed synthesis approach for inorganic nanomaterial synthesis was aimed.
For this purpose, an amyloid like peptide sequence which is capable of self-assembling into nanofibers in convenient conditions was designed and decorated with functional groups showing relatively high affinity to special inorganic ions, which are presented at the periphery of the one-dimensional peptide nanofibers. These chemical groups facilitated the deposition of targeted inorganic monomers onto the nanofibers yielding one-dimensional organic-inorganic core-shell nanostructures. The physical and chemical properties of the synthesized peptide nanofibers and inorganic nanostructures were characterized using both qualitative and quantitative methods. The results obtained in these studies encourage use of a new bottom-up synthesis approach. In the second part of the talk, a new concept of transient materials for bioelectronics and biomedical applications will be presented.
In this part, the precise control over transiency of polymer composites based on biocompatible and biodegradable polymers is demonstrated. These transient materials can be used in fabrication of bioelectronic devices, which are capable of dissolving in their surrounding environment with no traceable remains; and, maintain full functionality until triggered for degradation. Further, precise control over degradation of these biodegradable polymers serve as matrix for encapsulation of susceptible bioactive materials, such as proteins and growth factors. These non-toxic degradable polymers are suitable platforms for slow-delivery of bioactive materials with tunable mechanical properties to match that of the host living tissue.