Visualizing Nanoscale Dynamics in Liquids with High Spatial and Temporal Resolution Using Liquid Cell TEM
Abstract: Liquid-cell transmission electron microscopy is a powerful technique that allows to us visualize phenomena that take place in a liquid environment with the resolving power of a transmission electron microscope (TEM). In this presentation, I will show two examples of how liquid-cell TEM can be used to study chemical reactions involving nanoparticles and the dynamics of nanoparticles. First, I will discuss results from experiments where we followed the microstructural evolution of silver nanocubes as they undergo galvanic replacement with gold ions to understand mechanisms behind hollow structure formation. Then, I will talk about how we can track both the translation and rotation of nanoparticles contained within these liquid cells with temporal resolution of a few milliseconds. Lastly, I will discuss the potential impact of high-speed direct electron cameras on the field. In particular, I will touch on the strategies we are developing at the Center for BioImaging Sciences to achieve low-electron-dose imaging conditions for our experiments and the challenges in working with the large datasets that result from these experiments.