The pathological biochemical process leading to brain hypoxia, and then to stroke, was redirected to the in situ synthesis of biocompatible Au nanoparticles (NPs) near the hypoxia site, restoring the brain tissue redox status.
Significance and Impact
The proposed approach can be implemented not only in the brain but also in transplant tissues and other organs vulnerable to oxygen deficiency (e.g., heart, liver, kidney). We note the 2019 Nobel Prize in physiology and medicine was awarded for discoveries of how cells sense and adapt to oxygen availability.
- Synthesis of Au NP control samples and UV-visible spectroscopy and transmission electron microscopy of extracted gold (Au) NPs from tissue samples were performed at the Center for Nanoscale Materials (CNM).
- X-ray scattering measurements were performed at the Advanced Photon Source (APS).
Work was performed in part at CNM and APS.
About Argonne’s Center for Nanoscale Materials
The Center for Nanoscale Materials is one of the five DOE Nanoscale Science Research Centers, premier national user facilities for interdisciplinary research at the nanoscale supported by the DOE Office of Science. Together the NSRCs comprise a suite of complementary facilities that provide researchers with state-of-the-art capabilities to fabricate, process, characterize and model nanoscale materials, and constitute the largest infrastructure investment of the National Nanotechnology Initiative. The NSRCs are located at DOE’s Argonne, Brookhaven, Lawrence Berkeley, Oak Ridge, Sandia and Los Alamos National Laboratories. For more information about the DOE NSRCs, please visit https://science.osti.gov/User-Facilities/User-Facilities-at-a-Glance.
About the Advanced Photon Source
This research used resources of the Advanced Photon Source, a U.S. DOE Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory under Contract No. DE-AC02-06CH11357.
Argonne National Laboratory seeks solutions to pressing national problems in science and technology. The nation’s first national laboratory, Argonne conducts leading-edge basic and applied scientific research in virtually every scientific discipline. Argonne researchers work closely with researchers from hundreds of companies, universities, and federal, state and municipal agencies to help them solve their specific problems, advance America’s scientific leadership and prepare the nation for a better future. With employees from more than 60 nations, Argonne is managed by UChicago Argonne, LLC for the U.S. Department of Energy’s Office of Science.
The U.S. Department of Energy’s Office of Science is the single largest supporter of basic research in the physical sciences in the United States and is working to address some of the most pressing challenges of our time. For more information, visit https://energy.gov/science.