A microfluidic device was developed capable of simultaneous sensing of glutamate (GLU) and gamma-aminobutyric acid (GABA) in vivo, at faster (sub-second vs minutes) times, and higher accuracy (26x higher for GABA and 4x higher for GLU) than existing methods.
Significance and Impact
Allows brain-implant investigation of neurobiological mechanisms and disease symptoms of various brain disorders.
- Specific enzymes micro-spotted onto electrodes decompose GLU and GABA generating H2O2, which is detected amperometrically.
- A microchannel allows injecting calibration fluid or drugs.
- Center for Nanoscale Materials (CNM) cleanroom capabilities: MLA laserwriter, MA6 mask aligner, Oxford 100 ICP-RIE, March REI, XeF2 etcher, SEM, AJA sputtering system, profilometers, optical microscopes and AFM.
Work was performed in part at CNM.
About Argonne’s Center for Nanoscale Materials
The Center for Nanoscale Materials is one of the five DOE Nanoscale Science Research Centers, premier national user facilities for interdisciplinary research at the nanoscale supported by the DOE Office of Science. Together the NSRCs comprise a suite of complementary facilities that provide researchers with state-of-the-art capabilities to fabricate, process, characterize and model nanoscale materials, and constitute the largest infrastructure investment of the National Nanotechnology Initiative. The NSRCs are located at DOE’s Argonne, Brookhaven, Lawrence Berkeley, Oak Ridge, Sandia and Los Alamos National Laboratories. For more information about the DOE NSRCs, please visit https://science.osti.gov/User-Facilities/User-Facilities-at-a-Glance.
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