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Education and Outreach Programs

Lockport Township High School ESRP 2019

Optimizing Data Collection at Beamline 17-ID Using Bovine Insulin

Authors:

  • Students:
    • Ameera Abu-Khalil
    • Marissa Bollnow
    • Alette Eide
    • Eric Keta
    • Michael O’Callaghan
    • Thomas Wolf
  • Teachers:
    • William Kane
    • Karen Murphy
  • Mentors:
    • Erica Duguid (Argonne National Laboratory, Advanced Photon Source, IMCA-CAT, Sector 17; Hauptman Woodward Medical Research Institute, Sector 17)

Advanced Photon Source Sector 17: IMCA-CAT

Beamline 17-ID is operated by IMCA-CAT, a collection of pharmaceutical companies, to analyze samples for drug discovery. The beamline 17-ID is unique, and thus attempting to optimize the beamline’s settings may improve beamline research and exposure by increasing its efficiency for all those who use it. The student researchers proposed to provide other beamline users with statistical data of preset data collection settings that would help them potentially reduce the time that is needed to shoot their samples; therefore, beamline users’ time would be more cost-effective. The statistical data collected by the students on the beamline 17-ID may be used as a starting point for the testing of samples with similar characteristics to bovine insulin. The data collected and analyzed last year using Rmerge values suggested that a more in-depth study over a smaller range of exposure times would be beneficial. This year, the students focused in on a narrow range of exposure times that were highlighted from last year’s data.

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