Chain Reaction Innovations (CRI) capitalizes on the unique R&D tools and expertise at Argonne National Laboratory and the strong entrepreneurial ecosystem of the Midwest to bridge the commercialization “Valley of Death” between the research bench and the marketplace. Innovation ideas typically stall because of a lack of investment and a shortage in the mentoring support needed to build strong business plans that attract commercial partners or customers. CRI’s support system compresses development time and trains future entrepreneurs to create a bridge across this Valley of Death.