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Technology Commercialization and Partnerships

Automatic Cryoloop Alignment for Protein Crystals (IN-06-117)

Argonne licensing opportunity

Methods and apparatus for implementing robust and efficient cryoloop auto-centering for crystal location and alignment to the x-ray beam are provided. Image processing techniques are used for recognition of the small protein crystals. The detected crystal location enables crystal positioning in the x-ray beam, and optimization of the x-ray optics such as beam profile and intensity to the size and shape of the protein crystals.