Skip to main content
Press Release | Argonne National Laboratory

Argonne wins two R&D 100 awards for breakthroughs in protein crystallography and nanotechnology research

ARGONNE, Ill. — Two innovative technologies that enhance the ability to study nanomaterials and large biological proteins have won R&D 100 awards, regarded as the Oscars of invention,” for the U.S. Department of Energy’s Argonne National Laboratory.

The awards recognize the top scientific and technological innovations of the past year as judged by a team of independent experts for R&D magazine. Argonne scientists have won 108 R&D 100 awards since they were first introduced in 1964.

I want to congratulate all of this year’s winners on their awards and to thank them for their work,” Energy Secretary Steven Chu said. The large number of winners from the Department of Energy’s national labs every year is a clear sign that our labs are doing some of the most innovative research in the world. This work benefits us all by enhancing America’s competitiveness, ensuring our security, providing new energy solutions and expanding the frontiers of our knowledge. Our national labs are truly national treasures, and it is wonderful to see their work recognized once again.”

This year’s winners from Argonne are:

  • The π Steradian Transmission X-ray Detector for Nanoparticle Analysis in Electron Optical Beam Lines
  • Hard X-ray Quad Collimator

The π Steradian Transmission X-ray Detector

Argonne’s π Steradian Transmission X-ray Detection System is an innovative transformation of a technology used by the scientific community for 40 years. This R&D 100 winner significantly improves the ability of researchers to study nanomaterials. For the majority of scanning electron microscopes, transmission electron microscopes and scanning-transmission electron microscopes used today, more than 98 percent of the available X-ray signal from the microscopes is neglected.

Under conditions where signal is plentiful, this loss may not be a major issue. However, for studying minute quantities of material or materials that are beam-sensitive, such as nanoparticles and catalysts, or during time-sensitive measurements, the magnitude of the available signal becomes a limiting factor in an analysis.

Argonne’s technology solves this problem by increasing the detection of available signal during micro/nanoscale analysis of ultra-small particles and films as much as 500 times.  This is particularly important when using the sub-nanometer beams available in today’s atomic resolution electron-optical beam lines.

Funding for this research was provided by DOE’s Office of Science.

The principal developer is Nestor J. Zaluzec, senior scientist of Argonne’s Electron Microscopy Center.

Hard X-ray Quad Collimator

The advent of high-quality, third-generation X-ray sources, such as Argonne’s Advanced Photon Source, have provided new advantages to protein crystallographers. One such benefit is the use of mini X-rays beams, which can be created in two ways: by using optical elements to reduce the focus size of the incident X-ray beam, or by using collimating devices to sample portions of a focused beam.

The Hard X-ray Mini-beam Quad Collimator consists of three essential components: a uni-body quad collimator, a magnetically indexed kinematic mount and a precision motion system. The system provides micron-sized beams of various sizes to a sample. It is compact, durable and economical, and its motions are reproducible and precise at the micron level. It can be placed on beamlines or other X-ray sources.

Funding was provided by National Institute of Health’s National Institute of General Medical Sciences and National Cancer Institute.

The Hard X-ray Mini-beam Quad Collimator was jointly developed by a team from Argonne and the Life Sciences Institute of University of Michigan.

The principal developers from Argonne are Robert Fischetti, senior physicist; Shenglan Xu,  principal beamline engineer; Nagarajan Venugopalan, protein crystallographer; Derek W. Yoder, beamline specialist; Ruslan Sanishvili, protein crystallographer; Michael Becker, protein crystallographer; Craig Ogata, protein crystallographer; Sergey Stepanov, controls group leader; Oleg Makarov, principal control systems developer; Mark Hilgart, software developer senior; Sudhir Pothineni, software developer senior; and Steve Corcoran, engineering specialist. The principal developer from the University of Michigan is Janet L. Smith, director of the Life Sciences Institute.

Nanoscientist Nestor Zaluzec, above, won an R&D 100 award for his development of a nanoparticle detector.