We develop in vitro and in silico methods to improve understanding of microorganisms, their metabolisms, and their interactions.

Microbial community analysis and prediction aims to explore the part of the biosphere that controls 99% of the biochemistry on planet earth.

The Microbial Systems and Computational Biology group aims to understand the distributions of functions that natural microbial communities exhibit at different scales.

Proteins such as antibodies and enzymes represent a rich source of molecular recognition tools and catalytic reagents unmatched in other materials.

Using light-source-based X-ray structural molecular biology, our group studies macromolecules and their interactions, facilitating understanding of cellular processes and helping to define biological concepts.

Argonne’s Subsurface Biogeochemical Research Program seeks to identify and understand hydrobiogeochemical transformations of iron and sulfur.