According to the National Cancer Institute, 2018 saw an estimated 1.7 million new cases of cancer diagnosed and national expenditures for cancer care of nearly $150 billion. Cancer is the second-most common cause of death in the United States. To answer these challenges and establish a new paradigm in cancer research, Argonne is leading a collaboration of three other Department of Energy (DOE) national laboratories with the National Cancer Institute (NCI) of the National Institutes of Health (NIH) to address cancer research challenges, coupling the laboratories’strength in high-performance computing (HPC), machine learning, and data analytics with NCI’s expertise in cancer biology and healthcare delivery — applying the full promise of exascale computing to cancer and precision medicine.