The Advanced Supply Chain Analytics (ASCA) initiative brings to bear a diverse set of data analytics, modeling, simulation, and visualization tools upon the challenge of assuring or denying complex supply chains. ASCA convenes stakeholders and experts from across the national lab complex to advance mechanisms that balance supply chain risk and efficiency, respond to disruptive trends and technologies, optimize for cost effective resilience, assess the consequences of disruptions to complex interdependent supply chains, and address the challenges of evolving threat and technology landscapes.