Publication
Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria
Authors
Inniss, Nicole; Minasov, George; Chang, Changsoo; Tan, Kemin; Kim, Youngchang; Maltseva, Natalia; Stogios, Peter; Filippova, Ekaterina; Michalska, Karolina; Jaroszewki, Lukasz; Joachimiak, Andrzej; Satchell, Karla
Abstract
Antibiotic resistance remains a leading cause of severe infections worldwide. Small changes in protein sequence can impact antibiotic efficacy. Here, we report deposition of 58 X-ray crystal structures of bacterial proteins that are known targets for antibiotics, which expands knowledge of structural variation to support future antibiotic discovery or modifications.