Abstract: Crystallography is the leading technique to study atomic structures of proteins and produces enormous volumes of information that can place strains on the storage and data transfer capabilities of synchrotron and free-electron laser light sources. Lossy compression has been identified as a possible means to cope with the growing data volumes; however, prior approaches have not produced sufficient quality at a sufficient rate to meet scientific needs.

This paper presents Region Of Interest BINning with SZ lossy compression (ROIBIN-SZ) a novel, parallel, and accelerated compression scheme that separates the dynamically selected preservation of key regions with lossy compression of background information. We perform and present an extensive evaluation of the performance and quality results made by the co-design of this compression scheme. We can achieve up to a 196x and 46.44x compression ratio on lysozyme and selenobiotinyl-streptavidin while preserving the data sufficiently to reconstruct the structure at bandwidths and scales that approach the needs of the upcoming light sources.  We then conclude with paths forward to extend this to additional types of light source datasets.