Abstract: The Compact Linear Collider (CLIC) is a mature option for a future electron-positron collider operating at center-of-mass energies of up to 3 TeV. A detailed overview of the CLIC physics opportunities is presented. These are best exploited in a staged construction and operation scenario. The first stage at 380 GeV is optimized for precision measurements of the Higgs boson and top quark. The higher energy stages, currently assumed to be at 1.5 and 3 TeV, significantly enhance the sensitivity to new phenomena through direct and indirect measurements. The physics potential of upgrades to even higher energies using novel accelerator techniques is briefly discussed.