
This invention describes a system for crystallization and data collection of proteins using fixed-target serial crystallography using microfluidic droplet crystallography for the generation of uniform small crystals and a nylon mesh holder for positioning of droplets with crystal (or batch crystal slurries). While the use of nylon has previously been reported in the literature, this invention includes a method and device design for sealing the droplet/slurry loaded mesh between Mylar sheets.