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  • This software uses trained machine learning algorithms to classify features in a scanning tunneling microscopy (STM) topography, and feeds the results to a custom automated atomic manipulation subroutine, thereby circumventing the requirement for operator
    Intellectual Property Available to License

    Invention Opportunity & Solution


    • This program will allow for the building of complex structures that were previously unattainable.
    • The automation will save the operator time.


    Applications, Industries

    • Scanning probe microscopy software development
  • Polybot is a modular self-driving laboratory software environment that combines artificial intelligence (AI), automation, and experimentations. The robotics software of Polybot facilitates the rapid setup of hardware modules, implementation of experimenta
    Intellectual Property Available to License

    A flexible user scripting interface for the definitions of robot-performed experimental procedures

    Opportunity & Solution

    Autonomous experiments require orchestrating robotic movements and functions of hardware modules to perform a sequence of experimental steps designed and specified by a user who is familiar with the type of experiments (peptide synthesis, nanostructure characterization, etc.), but not necessarily accustomed to robotics hardware or computer programming. Our workflow scripting interface utilizes the Python programming language to simplify the scripting of hardware control sequences, and organizes them into logical entries that represent experimental steps. The entire experimental procedure is encompassed within a single script, allowing easy archival. The design enables sophisticated backend processing of the workflow script to enable seamless integration with machine learning/optimization frameworks and the robotics system control. Since the experimental procedure is presented in a form that resembles the original hardware control sequences, a wide range of experimental workflows and hardware configurations can be programmed with ease due to the readability and flexibility of the Python scripting language.


    • flexible scripting (no hidden codes)
    • experimental steps embedded clearly in control sequences
    • minimal programming skills required


    A ML-based scheduler for concurrent sample processing in autonomous experiments

    Opportunity & Solution

    A scheduler is as a software component that orchestrates the execution of steps (e.g., robot arm movement, solution stirring, temperature annealing, etc.) for performing an autonomous experiment. It is challenging to build a scheduler that enables seamless integration of non-vendor specific hardware and can efficiently optimize the execution order of steps in an experiment involving multiple hardware modules and concurrent processing of samples. Our software comprises a new scheduler using the widely used Python programming language. Since it is built using a general language that is increasingly common in the robotics and scientific fields, one can easily couple it with script-based hardware APIs and utilize machine learning to provide automatic data-driven tuning and hardware-aware scheduling of experimental steps. The ease of integration with existing software codes enables faster progress to be made across laboratories and reduces the cost of autonomous systems thus making them available to less well-funded laboratories.


    • Enables high-throughput material processing and synthesis
    • Leverages machine learning for closed-loop experiments
    • Fully autonomous


    Data structure and data workflow for handling material samples in high-throughput experiments

    Opportunity & Solution

    High-throughput experiments enabled by robotics generate large volumes of heterogeneous data, coming from multiple hardware modules in different data formats. There needs to be an easy way to standardize data and store them in a universal format such that data and metadata of individual material samples are well organized. This software consists of a material sample data class/object that utilizes JSON file in the backend for data storage. The sample data class is implemented using the Python programming language. It couples the flexibility of JSON files with rigid schema to make data files compatible with database handling. There are also functions for smart creation of unique sample ID based on workflow and input parameters, as well as handling the underlying data writing and conversion. Instead of the traditional approach of specifying file paths within an experimental workflow, we developed an object/data-oriented approach that initiates actions from the sample data class, providing an elegant way of handling the file path related issues in concurrent/parallel processing of material samples.


    • Designed to handle autonomous workflow
    • User-friendly content addition and editing
    • Data hierarchy designed for material samples


    Inventions, Applications, Industries:

    • Autonomous material discovery
    • Combinatorial experiments
    • High-dimensional processing-property relationships


    Lab automation:

    • Facilitates integration solutions for new instruments
    • Avoids resource deadlocks
    • Dynamic workflow adjustments


  • An atomistic simulation toolkit for bridging length and time scales.Invention: Multi-fidelity scale bridging between various flavors of molecular dynamics (i.e. ab-initio, classical and coarse-grained models) has remained a long-standing challenge.
    Intellectual Property Available to License


    Multi-fidelity scale bridging between various flavors of molecular dynamics (i.e. ab-initio, classical and coarse-grained models) has remained a long-standing challenge. BLAST (Bridging Length/time scales via Atomistic Simulation Toolkit) is a framework that leverages machine learning principles to address this challenge.

    Opportunity and Solution 

    BLAST provides users with the capabilities to train and develop their own classical atomistic and coarse-grained interatomic potentials (i.e., force fields) for molecular simulations. BLAST is designed to address several long-standing problems in the molecular simulation community, such as unintended misuse of existing force fields due to a knowledge gap between developers and users, bottlenecks in traditional force field development approaches, and other issues relating to the accuracy, efficiency, and transferability of force fields. The BLAST architecture consists of a web user-friendly interface, front-end and back-end web services, and machine learning algorithms that run on high-performance computing (HPC) clusters.

  • SDN Multiple Operating System Rotational Environment (SMORE) utilizes software defined networking (SDN) to programmatically switch the flow of packets from users to a given set of servers. By periodically switching which servers respond to user requests.
    Intellectual Property Available to License

    Cybersecurity issues are a day-to-day struggle for businesses and organizations. Keeping information secure can be a herculean task. SMORE-MTD, developed by Argonne’s Joshua Lyle and Nate Evans with laboratory funding, defends against cybersecurity attacks by using software-defined networking to manipulate network paths that service user requests.

    By randomly selecting which server and service will respond to a given user’s request, SMORE-MTD makes it more difficult for an attacker to identify which services to attack. SMORE-MTD also increases organizations’ resilience by preventing an attacker exploit from being routed to the vulnerable software, forcing attackers into repeated attacks that are more likely to be noticed. SMORE-MTD also eliminates the need to install and maintain configuration software on each host in rotation, which reduces complexity and increases the amount of software available for use.

  • Software Licensing Agreements

    Argonne researchers have developed both open-source and commercial software tools and suites which are available to license.
  • SVTRIP generates a naturalistic vehicle speed profile for a given route, which can be used to predict vehicle energy consumption and operations.
    Intellectual Property Available to License

    SVTRIP (Stochastic Vehicle Trip Prediction) generates a naturalistic vehicle speed profile (vehicle speed as a function of time at 1 Hz or more) for a given trip or route. The trip provided as an input is defined by the attributes of its sub-segments, such as travel time, distance and speed limit. The inputs can be provided directly by the user, extracted from digital maps, or generated from macroscopic or mesoscopic traffic flow simulators. The generated speed profiles can be used to predict vehicle energy consumption and operations for trips with low-resolution information. The algorithm used for generation relies on Markov Chains, making the generated speed profiles stochastic.

  • Venue assessment tool created to assess both cyber and physical vulnerabilities
    Intellectual Property Available to License

    SPARTA is a mobile supported venue assessment tool created to assess both cyber and physical vulnerabilities in stadiums and arenas.


    • Web-based application
    • Requires professional regular maintenance
    • Non-executable software

    Technical Requirements:

    • Multi-Platform
    • Web based tool currently running on linux.