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Argonne National Laboratory

Genesis Mission Research Projects

Argonne is leading and collaborating on a sweeping portfolio of AI-driven research projects as part of the Genesis Mission. This research aims to accelerate discovery on some of the nation’s most complex challenges and redefine how scientists harness AI at the frontiers of science and technology. 

Lead projects

Principal Investigator

Lead Institution

Project Title

Whitney Armstrong

Argonne National Laboratory

Superconducting Polychronous Computation Near Criticality

Bethany Dean-Kersten

Argonne National Laboratory

AI-Enabled Digital Twins for Commercializing Fuel Recycling and Securing Advanced Reactor Fuel Supply Chains

Yan Feng

Argonne National Laboratory

Physics-Informed Machine Learning of Cloud Microphysics for High-Resolution Earth System Modeling with Observationally Constrained Online Training

Calem Hoffman

Argonne National Laboratory

An Active-Learning Prioritization Engine for Nuclear Data Relevant to X-Ray Bursts

Anna McCoy

Argonne National Laboratory

AI-Enabled Optimization of Quantum Circuit Design for Realistic Nuclear Problems

Antonino Miceli

Argonne National Laboratory

CMOS + X: AI-Enabled Cross-Domain Co-Design for Low-Temperature Electronics, Sensors and Computation

Bogdan Nicolae

Argonne National Laboratory

SPOTTER-AI: Scientific Provenance-Oriented Threat Tracing and Attribution for Genesis Workflows

Eugene Yan

Argonne National Laboratory

Multi-Fidelity AI Foundation Model for Coupled Surface-Groundwater Predictions of Water Availability and Flood Hazards Across CONUS

Partner projects

Argonne Principal Investigator

Lead Institution

Project Title

Kartiek Agarwal

Virginia Tech

AI-Enabled Co-Design of Fault-Tolerant Logical Interface in Quantum LDPC Codes

Adarsha Balaji

SRI International

Scalable Heterogeneous Federated Learning Framework (SHFL)

Ramesh Balakrishnan

University of Southern California

AI-Driven Subgrid-Scale Model for Large-Eddy Simulation of Turbulent

David Bettinardi

SHINE Technologies

AI-Guided Fuel Cycle Facility Optimization

Benjamin Blakely

University of Hawaii

STRATOS: Security and Trust Runtime Architecture for Time-critical Operational Science

Simon Corrodi

University of South Carolina

Expedited Discovery by Leveraging Agentic Workflows for the Mu2e Charged Lepton Flavor Violation Search

Massimiliano Delferro

Northwestern University

Agentic AI-Driven Co-Optimization of a Tandem Electro-Thermocatalytic Route to Energy-Atom-Efficient Polyethylene Manufacturing from Waste Carbon

Sheng Di

North Carolina State University

An Agentic LLM Workflow for Code Generation and Optimization on Emerging AI Accelerators

Sheng Di

University of North Carolina at Charlotte

CASCADE: Composable Assurance for AI-enabled Scientific Computing with Agentic Error Governance

Jiwen Fan

Lawrence Livermore National Laboratory

Scalable Twin for Intelligent Turbulence and Cloud Heuristics (STITCH)

Jiwen Fan

Virginia Tech

Advancing Multimodal and Multidimensional AI to Discover Connections between Cloud Microphysics and Precipitation

Virendra Ghate

Iowa State University

A Spatial Generative Bayesian Computation Framework for Inferring Turbulence-Microphysics Interactions

Aaron Greco

Clemson University

AI-Driven Design and Control for Performance and Durability

Christopher Henry

California Institute of Technology

AI-Driven Prediction of Emerging Microbial Phenotypes in Electrogenic Consortia Across Scales

Nathaniel Hoyt

Aclara Technologies

AI-Enabled Process Optimization for Multi-Feed Rare Earth Separation

Rui Hu

Texas A&M University

SHIELD: Secure Human-in-the-loop Intelligence for Engineering and Licensing Deployment of Advanced Nuclear Systems

Andrzej Joachimiak

Rice University

Predictive AI to Map Point Mutation Effects on Protein Function: Measurement and Biosynthesis of Isoprenoids

Sylvester Joosten

University of Wisconsin-Madison

Principles of Foundation Models for Particle and Nuclear Physics

Peter Kenesei

University of Michigan

AI-Enabled Real-Time Reconstructions and Interpretation for Rapid 3D X-Ray Diffraction and Imaging of Materials Under Stress and Extreme Environments

Ji Liu

University of Pittsburgh

Accelerating Measurement-Based Quantum Simulation Software Design with Artificial Intelligence

Bernhard Maass

Texas A&M University

Scalable Agentic Digital Twins for Autonomous Precision Facilities

Ravi Madduri

Iowa State University

DAISY: Decentralized Agentic Intelligence System for Scientific Inquiry

Daniel Maldonado

Pacific Northwest National Laboratory

Accelerating Electromagnetic Transient Analysis through Physics-Informed Scalable Artificial Intelligence Models for Rapid Load Growth

Mark Messner

Oak Ridge National Laboratory

SMART-AI for Scale-Up and MAterial Reliability Translation of Advanced Structural Alloys for Fusion Applications

Brahim Mustapha

Michigan State University

Towards Self-Evolving, Physics-Informed Digital Twins of Ion Accelerators and Isotope Separators

Bogdan Nicolae

University of Utah

Dispatchable Data Centers: AI-Driven Workload Flexibility for Grid-Aware Load Shaping

John Power

Fermi National Accelerator Laboratory

AI/ML Resonance Control for High-Reliability, Low-Cost Accelerator Operations

Arvind Ramanathan

Carnegie Mellon University

Robust, Efficient, Scalable Cross-Cutting AI-Based Stack to Leverage Multiple Heterogenous Autonomous Labs for Massively Parallel Experiments

Arvind Ramanathan

University of Illinois Urbana-Champaign

Foundation Models for Metabolic Engineering

Paul Reimer

Stony Brook University

Foundation Models for Transferable Particle Tracking in Nuclear Physics

Patrick Shriwise

University of Wisconsin-Madison

Stellarator Blanket Optimization with Differentiable Monte Carlo Neutronics

Richard Vilim

Idaho National Laboratory

Prometheus

Pamela Weisenhorn

University of Maine

Bridging Genomics and Reactive Transport Models with AI for Subsurface Prediction

Jianguo Wen

Ohio State University

AI for Orbital Electronics Materials and Manufacturing

Christian White

 

Georgia Tech

AI-Enabled Single Cell Phenotyping to Advance Biomanufacturing

Brian Wyatt

Northeastern University

Self-Driving Discovery and Co-Design of MXene Memristors for 3D Compute-in-Memory System