UAB scientists use Argonne’s APS to fight influenza at the molecular level
Each year, influenza kills 250,000 to 500,000 people worldwide. Because viruses are noted for quick changes that produce pandemic strains against which few people have immunity, the need to develop novel antiviral compounds is great. Molecular virologist Chad Petit led a team of scientists at the University of Alabama at Birmingham to research ways to fight influenza. The team used the ultrabright X-rays from the Advanced Photon Source (APS), a U.S. Department of Energy (DOE) Office of Science User Facility, located at DOE’s Argonne National Laboratory, to study proteins from two distinctly different influenza strains.
Scientists using the APS do not work with live virus samples, but rather with crystals grown from proteins. X-rays diffract off the crystals and provide a picture of their atomic structures. The team identified two inhibitors: molecular mechanisms that, while not destroying the virus, stop it from blocking the body’s immune response. One of the proteins under study came from the H7N9 avian flu virus that affected poultry in China. The other came from the Spanish flu of 1918, a pandemic that infected one-third of the world’s population and killed 50 million to 100 million people.
University of Alabama team wins EcoCAR Mobility Challenge
A team from the University of Alabama has won Year Three of the latest EcoCAR Mobility Challenge, a DOE Advanced Vehicle Technology Competition (AVTC). EcoCAR provides graduate and undergraduate students with real-world, hands-on experience in designing and building next-generation mobility solutions. Launched in 2018, the program offers a challenging, real-world training ground for the next generation of automotive engineers.
Under the program, teams from 11 North American universities apply advanced propulsion systems, electrification, vehicle automation and connectivity to improve the energy efficiency of a 2019 Chevy Blazer while also balancing such aspects as emissions, safety and consumer acceptability.
Teams have four years to transform their vehicles from design concept into reality, building an energy efficient, connected and semi-automated vehicle. During the first two years, teams design and integrate their propulsion system into their car, and in Year Three they get behind the wheel to evaluate their model’s drivability, performance and energy efficiency. In Year Four, teams refine their vehicle to maximize its energy efficiency, safety and consumer acceptability. Argonne has managed the AVTCs for more than 30 years.