U-M collaborates with Argonne on anti-leukemia compound
An anti-cancer compound developed by University of Michigan (U-M) researchers could lead to a pivotal treatment, according to U-M researchers Jolanta Grembecka and Tomasz Cierpicki, who were the senior authors of the study in the Journal of Clinical Investigation in December 2019. The research demonstrated strong efficacy in mouse models of acute leukemia that represented up to 40 percent of human acute myeloid leukemia patients. The U-M team, along with colleagues from several institutions, furthered their research by using the high-brightness X-rays from the Advanced Photon Source at the U.S. Department of Energy’s Argonne National Laboratory.
The compound, called MI-3454, inhibits the leukemia-related protein, called menin, which plays a critical role in a subset of acute leukemia with poor clinical outcomes. MI-3454 offered a complete remission of leukemia in mouse models derived from the leukemia patient samples with chromosomal translocations in the Mixed Lineage Leukemia (MLL1) gene. These genetic rearrangements are found in 5 percent to 10 percent of adult acute leukemia patients and in 80 percent of acute lymphoblastic leukemias in infants. The research showed the mice lived longer and showed no signs of leukemia months after the treatment stopped. The compound also may be used for prostate cancer and Ewing sarcoma, the study said.
Argonne‘s electric battery technology boosts Michigan auto industries
The nickel-manganese-cobalt (NMC) blended cathode — developed by the U.S. Department of Energy’s Argonne National Laboratory -- enabled the widespread rollout of lithium-ion batteries throughout the marketplace. Since the development of this material nearly 15 years ago, Michigan-based industries have been at the epicenter of building the batteries that use this material and the cars that use the batteries. Argonne’s NMC blended cathode has led to multiple commercialization agreements and the building of manufacturing plants in Michigan and Ohio. NMC has become a prominent cathode material in the transportation market, with applications ranging from power tools to hybrid electric vehicles and could enable large-scale energy grid storage.
Another battery innovation comes from Tom Guarr, co-founder of Jolt Energy Storage Technologies LLC and a researcher at the Michigan State University Bioeconomy Institute in Holland, Michigan, who was chosen to participate in Argonne’s Chain Reaction Innovations in April 2018. Guarr is developing a small molecule that enables the production of a novel flow cell battery for energy storage. His work could revolutionize the field of energy storage.
Michigan State, Argonne collaborate on supernova research
A team of researchers led by Sean Couch, an assistant professor at Michigan State University, has been working with the U.S. Department of Energy’s (DOE) Argonne National Laboratory to perform extreme-scale simulations to help transform our understanding of core-collapse supernovae (CCSNe), the powerful explosions that mark the deaths of some massive stars. After the star exhausts its nuclear fuel, a runaway gravitational collapse of its core triggers an explosive process which creates almost all of elements heavier than iron in the universe and can leave behind an exotic remnant like a black hole, neutron star, pulsar or magnetar.
The team was awarded an allocation at the Argonne Leadership Computing Facility (ALCF) through DOE’s highly competitive Innovative and Novel Computational Impact on Theory and Experiment (INCITE) program. From 2018 through 2020, the team used ALCF’s Mira and Theta supercomputers to study the 3D dynamics of supernovae explosions, using realistic 3D models of massive progenitor stars, various starting conditions, while including rotation and magnetic fields along with other physical effects that influence the CCSNe mechanism and resulting observations.